The magnetic silica particles are available with a hydrophobic octadecyl (C18) surface, and can be delivered with an organic polymer shell (coreshell method) on request. Silica gel is odorless, insoluble & a non-conductor of electricity. They can be offered with the nickel(II) chelator nitrilotriacetic acid (NTA) or ready to use with the corresponding nickel complex (Ni-NTA) for the binding of histidine labeled proteins. Silica gel is suitable for drying or purification of acid vapors or liquids. ![]() The silica magnetic particles are also available with functional protein ligands (avidin, streptavidin, protein A, albumin) or biotin. Silica Gel in its Loose (Bulk) form is simply Silica Gel beads without any breathable packaging. in 1990, with improved efficiency and simplified operation. Loose Silica Gel (Bulk): Dry-Packs® bulk Silica Gel can adsorb up to 40 of its weight in moisture and has one of the highest moisture absorption rates available in any commercially available desiccants. Older children and grown-ups can mistake it for a package. It can also be used for nucleic acids isolation and purification though the DNA/RNA-silica interaction method created by Boom et al. A small child may find a silica gel packet and begin to chew on it. Carboxyl-functionalized magnetic silica nanoparticles and amine-terminated magnetic silica beads are known to be effective in protein isolation or macromolecule purification. ![]() Silica coating not only contributes to the improved stability and prolonged shelf-life due to inertness of silica, but also facilitates the surface functionalization by providing various active reacting groups, including OH, NH2, COOH, SH, N-hydroxysuccinimide (NHS) and epoxy for the covalent binding of proteins, antibodies, or other molecules. The non-functionalized magnetic silica nanoparticles (1 m being the most popular size) are frequently used for plasmid DNA/RNA isolation/extraction. They are extremely stable in organic solvents and at high temperatures. The Absolute Mag™ silica magnetic particles are produced by hydrolysis of orthosilicates in the presence of magnetite and have a hydrophilic surface with terminal Si-OH-bonds and can easily be separated with conventional permanent magnets.
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